Ing. Hana Dvořáková, CSc.

hana.dvorakova@vscht.cz 

linka 3840 (tel. 220 443 840)

Vzdělání a kvalifikace

 

1991

titul CSc. v oboru organická chemie na Ústavu organické chemie a biochemie Československé akademie věd (téma: Acyklická analoga nukleosidů a nukeotidů s modifikovanými purinovými basemi)

1978

titul Ing. v oboru organická chemie na VŠCHT Praha (téma: Elektrochemické oxidace benzofuranů)

Zaměstnání

 

1996–

vědecký pracovník v laboratoři NMR, VŠCHT Praha

1994

jednoroční pobyt na Organic Chemistry Department of the University of Leicester, GB

1983–1995

vědecký pracovník v Ústavu organické chemie a biochemie Československé akademie věd

Oblasti výzkumu

Aplikace NMR spektroskopie v oblasti kalixarenů, resorcinarenů a přírodních látek. Studium konformačních vlastností a dynamiky molekul, kinetika a termodynamika chemických reakcí.

Vybrané publikace

Lukášek, J.; Böhm, S.; Dvořáková, H.; Eigner, V.;  Lhoták, P., Regioselective Halogenation of Thiacalix[4]arenes in the Cone and 1,3-Alternate Conformations, (2014) Org. Lett. 16, asap doi: 10.1021/ol5024536

Botha, F.; Böhm, S.; Dvořáková, H.; Eigner, V.;  Lhoták, P., Mercuration of Thiacalix[4]?arenes in the Cone and 1,?3-?Alternate Conformations (2014)Org. Biomol. Chem. 12, 5136-5143  doi:10.1039/C4OB00799A

doi:

10.1039/C4CC02274B

Holub J., Eigner V., Vrzal L., Dvořáková H., Lhoták P. Calix[4]arenes with intramolecularly bridged meta positions prepared via Pd-catalysed double C-H activation. (2013) Chem. Com., 49(27),2798-2800. doi:10.1039/c3cc40655e

Váňa L.; Vrzal L., Dvořáková H., Himl M., Linhart I. Direct arylation of adenine by fluoro- and chloronitrobenzenes. Effect of microwaves. (2013) Synth. Com., 44(6), 788-799.doi:10.1080/00397911.2013.831902

Flidrova K., Bohm S., Dvorakova H., Eigner V., Lhotak P. (2014) Dimercuration of Calix[4]arenes: Novel Substitution Pattern in Calixarene Chemistry, Organic Letters, 16(1), 138-141. doi:10.1021/ol403133b

Menova P., Dvorakova H., Eigner V., Ludvik J., Cibulka R. (2013) Electron-Deficient Alloxazinium Salts: Efficient Organocatalysts of Mild and Chemoselective Sulfoxidations with Hydrogen Peroxide, Advanced Synthesis & Catalysis, 355(17), 3451-3462. doi:10.1002/adsc.201300617

Jurok R., Hodacova J., Eigner V., Dvorakova H., Setnicka V., Cibulka R. (2013) Planar Chiral Flavinium Salts: Synthesis and Evaluation of the Effect of Substituents on the Catalytic Efficiency in Enantioselective Sulfoxidation Reactions, European Journal of Organic Chemistry, 2013(34), 7724-7738. doi:10.1002/ejoc.201300847

Slavik P., Flidrova K., Dvorakova H., Eigner V., Lhotak P. (2013) Meta-arylation of calixarenes using organomercurial chemistry, Organic & Biomolecular Chemistry, 11(33), 5528-5534. doi:10.1039/c3ob41085d

Benesova E., Lipovova P., Dvorakova H. Kralova B. (2013) ?-L-Fucosidase from Paenibacillus thiaminolyticus: Its hydrolytic and transglycosylation abilities, Glycobiology, 23(9), 1052-1065. doi:10.1093/glycob/cwt041

Flidrova K., Slavik P., Eigner V,; Dvorakova H., Lhotak P. (2013) meta-Bridged calix[4]arenes: a straightforward synthesis via organomercurial chemistry, Chemical Communications, 49(60), 6749-6751. doi:10.1039/c3cc43284j

Holub J., Eigner V., Vrzal L., Dvorakova H., Lhotak P. (2013) Calix[4]arenes with intramolecularly bridged meta positions prepared via Pd-catalysed double C-H activation, Chemical Communications, 49(27), 2798-2800. doi:10.1039/c3cc40655e

Jurasek M., Dzubak P., Sedlak D., Dvorakova H., Hajduch M., Bartunek P., Drasar P. (2013) Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors. Steroids, 78(3), 356-361. doi:10.1016/j.steroids.2012.11.016

Mackova M., Himl M., Budka J., Pojarova M., Cisarova I., Eigner V., Curinova P., Dvorakova H., Lhotak P. (2013) Self-assembly of 5,11,17,23-tetranitro-25,26,27,28-tetramethoxythiacalix[4]arene with neutral molecules and its use for anion recognition. Tetrahedron, 69(4), 1397-1402. doi:10.1016/j.tet.2012.10.101

Hudecek O., Budka J., Dvorakova H., Curinova P., Cisarova I., Lhotak P. (2013) Anion receptors based on ureidocalix[4]arenes immobilised in the partial cone conformation. New Journal of Chemistry, 37(1), 220-227. doi:10.1039/c2nj40724h

Koukal, P., Dvorakova, H., Dvorak, D., Tobrman, T. (2013) Palladium-catalysed Claisen rearrangement of 6-allyloxypurines. Chemical Papers, 67(1), 3-8. doi:10.2478/s11696-012-0239-y

Tatar A., Dolensky B., Dvorakova H., Kral V. (2012) Selective formation of either Troeger's base or spiro Troeger's base derivatives from [2-aminoporphyrinato(2-)]nickel by choice of reaction condition. Tetrahedron Letters, 53(45), 6015-6017. doi:10.1016/j.tetlet.2012.08.097

Krovacek M., Dvorakova H., Votruba I., Cisarova I., Dvorak D. (2012) 6-Alkynylpurines bearing electron acceptor substituents: preparation, reactivity in cycloaddition reactions and cytostatic activity. Collection of Czechoslovak Chemical Communications, 76(12), 1487-1507. doi:10.1135/cccc2011176

Kundrat O., Dvorakova H., Bohm S., Eigner V., Lhotak P. (2012) S-Alkylation of Thiacalixarenes: How the Regio- and Stereoselectivities Depend on the Starting Conformation. Journal of Organic Chemistry, 77(5), 2272-2278. doi:10.1021/jo202571h

Kaminsky J., Dvorakova H., Stursa J., Moravcova J. (2011) Collection of Czechoslovak Chemical Communications, 76(10), 1199-1222. doi:10.1135/cccc2010104

Menova P., Eigner V., Cejka J., Dvorakova H., Sanda M., Cibulka R. (2011) Synthesis and structural studies of flavin and alloxazine adducts with O-nucleophiles. Journal of Molecular Structure, 1004(1-3), 178-187. doi:10.1016/j.molstruc.2011.08.002

Kundrat O., Eigner V., Dvorakova H., Lhotak P. (2011) S-Alkylation of Thiacalixarenes: A Long-Neglected Possibility in the Calixarene Family. Organic Letters, 13(15), 4032-4035. doi:10.1021/ol201546y

Menova P., Kafka F., Dvorakova H., Gunnoo S., Sanda M., Cibulka R. (2011) Pyrazinium Salts as Efficient Organocatalysts of Mild Oxidations with Hydrogen Peroxide. Advanced Synthesis & Catalysis. 353(6), 865-870. doi:10.1002/adsc.201000906

Jurok R., Cibulka R., Dvorakova H., Hampl F., Hodacova J. (2010) Planar Chiral Flavinium Salts - Prospective Catalysts for Enantioselective Sulfoxidation Reactions. European Journal of Organic Chemistry. (27), 5217-5224 doi:10.1002/ejoc.201000592

Chlubnova I., Filipp D., Spiwok V., Dvorakova H., Daniellou R., Nugier-Chauvin Caroline,. Kralova B., Ferrieres V. (2010) Enzymatic synthesis of oligo-D-galactofuranosides and L-arabinofuranosides: from molecular dynamics to immunological assays. Organic & Biomolecular Chemistry. 8(9), 2092-2102. doi:10.1039/b926988f

Dolensky B., Kvicala J., Paleta O., Lang J., Dvorakova H., Cejka J. (2010) Trifluoromethylated (tetrahydropyrrolo) quinazolinones by a new three-component reaction and facile assignment of the regio- and stereoisomers formed by NMR spectroscopy. Magnetic Resonance in Chemistry, 48(5), 375-385. doi:10.1002/mrc.2580

Benesova E., Lipovova P., Dvorakova H., Kralova B. (2010) ß-d-Galactosidase from Paenibacillus thiaminolyticus catalyzing transfucosylation reactions. Glycobiology, 20(4), 442-451. doi:10.1093/glycob/cwp196

Hornicek J., Dvorakova H., Bour P. (2010) Intramolecular Proton Transfer in Calixphyrin Derivatives. Journal of Physical Chemistry A, 114(10), 3649-3654. doi:10.1021/jp911598w

Zurek J., Cibulka R., Dvorakova H., Svoboda J. (2010) N 1,N 10-Ethylene-bridged flavinium salts derived from -valinol: synthesis and catalytic activity in H2O2 oxidations. Tetrahedron Letters, 51(7), 1083-1086. doi:10.1016/j.tetlet.2009.12.096

Kundrat O., Dvorakova H., Eigner V., Lhotak P. (2010) Uncommon Regioselectivity in the Thiacalix[4]arene Series: Gross Formylation of the Cone Conformer. Journal of Organic Chemistry, 75(2), 407-411. doi:10.1021/jo902240h

Kundrat, O., Dvorakova, H., Cisarova, I., Pojarova, M., Lhotak, P. (2009) Org. Lett. 11, 4188-4191. doi:10.1021/ol901812m

Keder, R., Dvorakova, H., Dvorak, D. (2009) Eur. J. Org. Chem. 1522-1531. doi:10.1002/ejoc.200801002

Simanova, M., Dvorakova, H., Stibor, I., Pojarova, M., Lhotak, P. (2008) Tetrahedron Lett. 49, 1026-1029. doi:10.1016/j.tetlet.2007.12.004

Dvorakova, H., Lang, J., Vlach, J., Sykora, J., Cajan, M., Himl, M., Pojarova, M., Stibor, I., Lhotak, P. (2007) J. Org. Chem. 72, 7157-7166. doi:10.1021/jo070927i

Tobrman, T., Meca, L., Dvorakova, H., Cerny, J., Dvorak, D. (2006) Organometallics 25, 5540-5548. doi:10.1021/om0605837

Dvorakova, H., Stursa, J., Cajan, M., Moravcova, J. (2006) Eur. J. Org. Chem. 4519-4527. doi:10.1002/ejoc.200600386

Bernatkova, M., Dvorakova, H., Andrioletti, B., Kral, V., Bour, P. (2005) J. Phys. Chem. A 109, 5518-5526. doi:10.1021/jp050746p

Dolensky, B., Kroulik, J., Kral, V., Sessler, J. L., Dvorakova, H., Bour, P., Bernatkova, M., Bucher, C., Lynch, V. (2004) J. Am. Chem. Soc. 126, 13714-13722. doi:10.1021/ja048075g

Novak, J., Linhart, I., Dvorakova, H. (2004) Eur. J. Org. Chem. 2738-2746. doi:10.1002/ejoc.200300811

Stastny, V., Stibor, I., Dvorakova, H., Lhotak, P. (2004) Tetrahedron 60, 3383-3391. doi:10.1016/j.tet.2004.02.036

Stursa, J., Dvorakova, H., Smidrkal, J., Petrickova, H., Moravcova, J. (2004) Tetrahedron Lett. 45, 2043-2046. doi:10.1016/j.tetlet.2004.01.080

Lhotak, P., Himl, M., Stibor, I., Sykora, J., Dvorakova, H., Lang, J., Petrickova, H. (2003) Tetrahedron 59, 7581-7585. doi:10.1016/S0040-4020(03)01171-2

Hocek, M. Dvorakova, H. (2003) J. Org. Chem. 68, 5773-5776. doi:10.1021/jo034351i

Dvorakova, H., Masojidkova, M., Holy, A., Balzarini, J., Andrei, G., Snoeck, R., DeClercq, E. (1996) J. Med. Chem. 39, 3263-3268. doi:

Dvorakova, H., Dvorak, D., Holy, A. (1996) Tetrahedron Lett. 37, 1285-1288.