3805 (tel. 220 443 805)
Education and qualifications
2014
Ph.D. student, Faculty of Food and Biochemical Technology, UCT Prague
(topic: Fragment-based drug design.)
2012-2014
Master’s degree in Synthesis and Production of Drugs, Faculty of Chemical Engineering, UCT Prague
(topic: Application of alignment media in structural analysis of calix[4]arenes.)
2009-2012
Bachelor’s degree in Chemistry, Faculty of Chemical Engineering, UCT Prague
(topic: Study of the spatial structure of isomers of bridged chiral calix[4]arene using residual dipolar coupling constants.)
Research interests
Structural study of small organic compounds (calix[n]arene derivatives) via NMR spectroscopy, especially using residual dipolar coupling constants (RDCs).
Fragment-based drug discovery using Saturation transfer difference (STD) and Water LOGSY (WL) techniques.
Publications
Vrzal L., Flídrová K., Tobrman, T., Dvořáková, H., Lhoták, P., Use of residual dipolar couplings in conformational analysis of meta-disubstituted calix[4]arenes. (2014) Chem. Com., 50(57), 7590-7592.
doi:10.1039/C4CC02274B
Váňa L.; Vrzal L., Dvořáková H., Himl M., Linhart I. Direct arylation of adenine by fluoro- and chloronitrobenzenes. Effect of microwaves. (2013) Synth. Com., 44(6), 788-799.
doi:10.1080/00397911.2013.831902
Holub J., Eigner V., Vrzal L., Dvořáková H., Lhoták P. Calix[4]arenes with intramolecularly bridged meta positions prepared via Pd-catalysed double C-H activation. (2013) Chem. Com., 49(27),2798-2800.
doi:10.1039/c3cc40655e